Trimethoprim

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Trimethoprim is the dihydrofolate-reductase inhibitor in Bactrim / Septra and the prophylactic of choice for UTIs and Pneumocystis. The molecule is a 2,4-diaminopyrimidine tethered by a methylene bridge to 3,4,5-trimethoxybenzene. Two cuts open it: snap the methylene off the aryl side (Knoevenagel), then close the pyrimidine ring back onto guanidine.

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Cell id: trimethoprim

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