Sitagliptin: spot the stereochemistry flaw

Single question

Asymmetric hydrogenation of a beta-enamino amide installs the stereocenter that defines sitagliptin. The substrate, the catalyst class, and the conditions match the Merck process. Check the absolute configuration on the product.

Rh-Josiphos asymmetric hydrogenation of enamines

(R) vs (S) enantiomer activity at DPP-4

Reading absolute configuration on beta-amino amides

Find the flaw

Click the step that contains the flaw, or pick “No flaw” if you think every step is correct.

Discussion

0 comments

Loading discussion...