Prostaglandin F2a: spot the regiochemistry flaw

Single question

Final Wittig in the Corey PGF2a synthesis attaches the lower alpha chain to the cyclopentane ring. Reagents and reaction class match. Check which cyclopentane carbon ends up with the new chain.

Prostaglandin numbering (C8, C12, C13)

Wittig reaction targets the carbon bearing the aldehyde, not a neighbor

Distinguishing the upper (omega) and lower (alpha) chain attachment points

Find the flaw

Click the step that contains the flaw, or pick “No flaw” if you think every step is correct.

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