Metformin: spot the conditions flaw

Single question

One-step biguanide formation from dimethylamine and dicyandiamide gives metformin. The reagents are right. Check the temperature.

Biguanide formation from cyanoguanidine

Activation energy for amine + nitrile-type addition

Melt vs aqueous conditions in industrial chemistry

Click the step that contains the flaw, or pick “No flaw” if you think every step is correct.

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