Losartan: spot the fabricated tetrazole step

Single question

Late-stage tetrazole installation completes the losartan synthesis. The biaryl scaffold and the imidazole arm look right. Check the chemistry that turns the biphenyl precursor into the tetrazole.

Tetrazole formation by NaN3 + nitrile cycloaddition

Distinguishing real vs fabricated reaction sequences

Losartan (Merck / DuPont) process

Find the flaw

Click the step that contains the flaw, or pick “No flaw” if you think every step is correct.

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