Fluorophosphonate warhead: spot the conditions flaw

Single question

Last step in a fluorophosphonate ABP synthesis: convert an octyl ethyl phosphonyl chloride to the fluoride. The reactant, product, and reaction class are all right. Check the medium.

Hydrolytic instability of P-F bonds

Anhydrous fluoride sources (DAST, AgF, anhydrous KF in DMF)

Why activity-based probes need to be assembled dry

Find the flaw

Click the step that contains the flaw, or pick “No flaw” if you think every step is correct.

Discussion

0 comments

Loading discussion...