Celecoxib: spot the pyrazole regiochemistry flaw

Single question

One-step pyrazole formation between a 1,3-diketone and an arylhydrazine gives celecoxib. The reactants are right. Read the pyrazole substitution pattern in the product.

Pyrazole regiochemistry from 1,3-diketones

Electronic vs steric control in pyrazole synthesis

Celecoxib vs its COX-1 selective regioisomer

Find the flaw

Click the step that contains the flaw, or pick “No flaw” if you think every step is correct.

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